Validation of a precision tremor measurement system for multiple sclerosis

T Perera; WL Lee; SAC Yohanandan; AL Nguyen; B Cruse; FMC Boonstra; G Noffs; AP Vogel; SC Kolbe; H Butzkueven; A Evans; A van der Walt

Journal article

Validation of a precision tremor measurement system for multiple sclerosis

T Perera, WL Lee, SAC Yohanandan, AL Nguyen, B Cruse, FMC Boonstra, G Noffs, AP Vogel, SC Kolbe, H Butzkueven, A Evans, A van der Walt

Journal of Neuroscience Methods | ELSEVIER SCIENCE BV | Published : 2019

DOI: 10.1016/j.jneumeth.2018.09.022

Abstract

Background: Tremor is a debilitating symptom of Multiple Sclerosis (MS). Little is known about its pathophysiology and treatments are limited. Clinical trials investigating new interventions often rely on subjective clinical rating scales to provide supporting evidence of efficacy. New Method: We present a novel instrument (TREMBAL) which uses electromagnetic motion capture technology to quantify MS tremor. We aim to validate TREMBAL by comparison to clinical ratings using regression modelling with 310 samples of tremor captured from 13 MS participants who performed five different hand exercises during several follow-up visits. Minimum detectable change (MDC) and test-retest reliability were..

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University of Melbourne Researchers

Thushara Perera Author

Ai-Lan Nguyen Author

Gustavo Noffs Author

Adam Vogel Author

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Grants

Awarded by Alexander von Humboldt-Stiftung

Funding Acknowledgements

We wish to thank the reviewers of this manuscript for their insightful comments and recommendations which led to significant improvements. This work was supported by grants from the National Health and Medical Research Council (NHMRC) Australia Project Grant (1085461 CIA Van der Walt), NHMRC Fellowship (1135683 Vogel), The Colonial Foundation and the St. Vincent's Research Endowment Fund. A/Prof Van der Walt is supported by an NHMRC Early Career Fellowship (1123330). Prof Butzkueven is supported by an NHMRC Practitioner Fellowship (1080518). A/Prof Vogel receives funding from an NHMRC Career Development Fellowship (1082910), and the Alexander von Humboldt Foundation, in addition to receiving institutional support from The University of Melbourne. Bionics Institute receives Operational Infrastructure Support from the Victorian Government.